Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux.
Franchi L, Eigenbrod T, Muñoz-Planillo R, Ozkurede U, Kim YG, Arindam C, Gale M Jr, Silverman RH, Colonna M, Akira S, Núñez G.J Immunol. 2014 Oct 15;193(8):4214-4222. doi: 10.4049/jimmunol.1400582. Epub 2014 Sep 15. PMID: 25225670
Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection.
Thackray LB, Shrestha B, Richner JM, Miner JJ, Pinto AK, Lazear HM, Gale M Jr, Diamond MS.J Virol. 2014 Oct;88(19):11007-21. doi: 10.1128/JVI.01545-14. Epub 2014 Jul 16. PMID: 25031348
In vitro and in vivo characterization of a West Nile virus MAD78 infectious clone.
Hussmann KL, Vandergaast R, Ochsner SP, Huang AC, Gale M Jr, Fredericksen BL.Arch Virol. 2014 Nov;159(11):3113-8. doi: 10.1007/s00705-014-2176-2. Epub 2014 Jul 15. PMID: 25023336
Pushing to a cure by harnessing innate immunity against hepatitis C virus.
Ireton RC, Gale M Jr.Antiviral Res. 2014 Aug;108:156-64. doi: 10.1016/j.antiviral.2014.05.012. Epub 2014 Jun 4. Review. PMID: 24907428
Pinto AK, Ramos HJ, Wu X, Aggarwal S, Shrestha B, Gorman M, Kim KY, Suthar MS, Atkinson JP, Gale M Jr, Diamond MS.
PLoS Pathog. 2014 Apr 17;10(4):e1004086. doi: 10.1371/journal.ppat.1004086. eCollection 2014 Apr. PMID: 24743949
IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice.
Spann KM, Loh Z, Lynch JP, Ullah A, Zhang V, Baturcam E, Werder RB, Khajornjiraphan N, Rudd P, Loo YM, Suhrbier A, Gale M Jr, Upham JW, Phipps S.Am J Pathol. 2014 Jun;184(6):1795-806. doi: 10.1016/j.ajpath.2014.02.026. Epub 2014 Apr 13. PMID: 24726644
Antiviral innate immunity: editorial overview.
Freed EO, Gale M Jr.J Mol Biol. 2014 Mar 20;426(6):1129-32. doi: 10.1016/j.jmb.2014.01.005. Epub 2014 Jan 22. No abstract available. PMID: 24462565
Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.
Ooi EL, Chan ST, Cho NE, Wilkins C, Woodward J, Li M, Kikkawa U, Tellinghuisen T, Gale M Jr, Saito T.Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1909-14. doi: 10.1073/pnas.1314268111. Epub 2014 Jan 21. PMID: 24449862
Innate antiviral immune signaling, viral evasion and modulation by HIV-1.
Rustagi A, Gale M Jr.J Mol Biol. 2014 Mar 20;426(6):1161-77. doi: 10.1016/j.jmb.2013.12.003. Epub 2013 Dec 8. Review. PMID: 24326250
Direct, interferon-independent activation of the CXCL10 promoter by NF-κB and interferon regulatory factor 3 during hepatitis C virus infection.
Brownell J, Bruckner J, Wagoner J, Thomas E, Loo YM, Gale M Jr, Liang TJ, Polyak SJ.J Virol. 2014 Feb;88(3):1582-90. doi: 10.1128/JVI.02007-13. Epub 2013 Nov 20. PMID: 24257594
The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs.
McFarland AP, Horner SM, Jarret A, Joslyn RC, Bindewald E, Shapiro BA, Delker DA, Hagedorn CH, Carrington M, Gale M Jr, Savan R.Nat Immunol. 2014 Jan;15(1):72-9. doi: 10.1038/ni.2758. Epub 2013 Nov 17. PMID: 24241692
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