2017

Interferon Lambda Genetics and Biology in Regulation of Viral Control.

Hemann EA, Gale M Jr, Savan R.
Front Immunol. 2017 Dec 6;8:1707. doi: 10.3389/fimmu.2017.01707. eCollection 2017. Review.

Protection of mice deficient in mature B cells from West Nile virus infection by passive and active immunization.

Giordano D, Draves KE, Young LB, Roe K, Bryan MA, Dresch C, Richner JM, Diamond MS, Gale M Jr, Clark EA.
PLoS Pathog. 2017 Nov 27;13(11):e1006743. doi: 10.1371/journal.ppat.1006743. eCollection 2017 Nov.

Dramatic enhancement of the detection limits of bioassays via ultrafast deposition of polydopamine.

Li J, Baird MA, Davis MA, Tai W, Zweifel LS, Adams Waldorf KM, Gale M Jr, Rajagopal L, Pierce RH, Gao X.
Nat Biomed Eng. 2017;1. pii: 0082. doi: 10.1038/s41551-017-0082. Epub 2017 Jun 5.

Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy.

Burchill MA, Roby JA, Crochet N, Wind-Rotolo M, Stone AE, Edwards MG, Dran RJ, Kriss MS, Gale M Jr, Rosen HR.
PLoS One. 2017 Oct 17;12(10):e0186213. doi: 10.1371/journal.pone.0186213. eCollection 2017. PMID: 29040318

Versican is Produced by Trif- and Type I Interferon-Dependent Signaling in Macrophages and Contributes to Fine-Control of Innate Immunity in Lungs.

Chang MY, Kang I, Gale M Jr, Manicone AM, Kinsella MG, Braun KR, Wigmosta T, Parks WC, Altemeier WA, Wight TN, Frevert CW.
Am J Physiol Lung Cell Mol Physiol. 2017 Sep 14:ajplung.00353.2017.  PMID: 28912382

RNA PAMPs as Molecular Tools for Evaluating RIG-I Function in Innate Immunity.

Ireton RC, Wilkins C, Gale M Jr.
Methods Mol Biol. 2017;1656:119-129.  PMID: 28808965

Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative Cross.

Green R, Wilkins C, Thomas S, Sekine A, Hendrick DM, Voss K, Ireton RC, Mooney M, Go JT, Choonoo G, Jeng S, de Villena FP, Ferris MT, McWeeney S, Gale M Jr.
Nat. Immunology. 2017 Jun 7;7(6):1665-1682. PMID: 2859264

The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.

Gorman JA, Hundhausen C, Errett JS, Stone AE, Allenspach EJ, Ge Y, Arkatkar T, Clough C, Dai X, Khim S, Pestal K, Liggitt D, Cerosaletti K, Stetson DB, James RG, Oukka M, Concannon P, Gale M Jr, Buckner JH, Rawlings DJ.
Nat Immunol. 2017 Jul;18(7):744-752. PMID: 28553952

RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation.

Daniels BP, Snyder AG, Olsen TM, Orozco S, Oguin TH 3rd, Tait SW, Martinez J, Gale M Jr, Loo YM, Oberst A.
Cell. 2017 Apr 6;169(2):301-313.e11.  PMID: 28366204

A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response.

Probst P, Grigg JB, Wang M, Muñoz E, Loo YM, Ireton RC, Gale M Jr, Iadonato SP, Bedard KM.
Vaccine. 2017 Apr 4;35(15):1964-1971.  PMID: 28279563

Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection.

Daniels BP, Jujjavarapu H, Durrant DM, Williams JL, Green RR, White JP, Lazear HM, Gale M Jr, Diamond MS, Klein RS.
J Clin Invest. 2017 Mar 1;127(3):843-856. PMID: 28134626

MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D.

Gutierrez KD, Davis MA, Daniels BP, Olsen TM, Ralli-Jain P, Tait SW, Gale M Jr, Oberst A.
J Immunol. 2017 Mar 1;198(5):2156-2164.  PMID: 28130493

MAVS Is Essential for Primary CD4+ T Cell Immunity but Not for Recall T Cell Responses following an Attenuated West Nile Virus Infection.

Luo H, Winkelmann E, Xie G, Fang R, Peng BH, Li L, Lazear HM, Paessler S, Diamond MS, Gale M Jr, Barrett AD, Wang T.
J Virol. v.91(6). Print 2017 Mar 15. PMID: 28077630

Correction: Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission.

Giugliano S, Petroff MG, Warren BD, Jasti S, Linscheid C, Ward A, Kramer A, Dobrinskikh E, Sheiko MA, Gale M Jr, Golden-Mason L, Winn VD, Rosen HR.
J Immunol. 2017 Jan 15;198(2):972. No abstract available. PMID: 28069758

RNA-Seq in the Collaborative Cross.

Green R, Wilkins C, Ferris MT, Gale M Jr.
Methods Mol Biol. 2017;1488:251-263. PMID: 27933528