2018

Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques.

O'Connor MA, Tisoncik-Go J, Lewis TB, Miller CJ, Bratt D, Moats CR, Edlefsen PT, Smedley J, Klatt NR, Gale M Jr, Fuller DH.
Nat Commun. 2018 Aug 22;9(1):3371. doi: 10.1038/s41467-018-05826-w.PMID: 30135445

Matrix metalloproteinase 28 is regulated by TRIF- and type I IFN-dependent signaling in macrophages.

Long ME, Gong KQ, Volk JS, Eddy WE, Chang MY, Frevert CW, Altemeier WA, Gale M Jr, Liles WC, Manicone AM.
Innate Immun. 2018 Aug;24(6):357-365. doi: 10.1177/1753425918791024. Epub 2018 Aug 1.PMID: 30068264

Correction for Kumar et al., "Inflammasome Adaptor Protein Apoptosis-Associated Speck-Like Protein Containing CARD (ASC) Is Critical for the Immune Response and Survival in West Nile Virus Encephalitis".

Kumar M, Roe K, Orillo B, Muruve DA, Nerurkar VR, Gale M Jr, Verma S.
J Virol. 2018 Jul 17;92(15). pii: e02176-17. doi: 10.1128/JVI.02176-17. Print 2018 Aug 1. No abstract available.PMID:30018145

Interferon-stimulated genes: new platforms and computational approaches.

Green R, Ireton RC, Gale M Jr.
Mamm Genome. 2018 Aug;29(7-8):593-602. doi: 10.1007/s00335-018-9755-6. Epub 2018 Jul 7. Review. PMID: 29982912

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates.

Dudley DM, Van Rompay KK, Coffey LL, Ardeshir A, Keesler RI, Bliss-Moreau E, Grigsby PL, Steinbach RJ, Hirsch AJ, MacAllister RP, Pecoraro HL, Colgin LM, Hodge T, Streblow DN, Tardif S, Patterson JL, Tamhankar M, Seferovic M, Aagaard KM, Martín CS, Chiu CY, Panganiban AT, Veazey RS, Wang X, Maness NJ, Gilbert MH, Bohm RP, Adams Waldorf KM, Gale M Jr, Rajagopal L, Hotchkiss CE, Mohr EL, Capuano SV 3rd, Simmons HA, Mejia A, Friedrich TC, Golos TG, O'Connor DH.
Nat Med. 2018 Aug;24(8):1104-1107. doi: 10.1038/s41591-018-0088-5. Epub 2018 Jul 2. PMID: 29967348

Immunoprofiles of human Sertoli cells infected with Zika virus reveals unique insights into host-pathogen crosstalk.

Strange DP, Green R, Siemann DN, Gale M Jr, Verma S.
Sci Rep. 2018 Jun 7;8(1):8702. doi: 10.1038/s41598-018-27027-7. PMID:29880853

Femur-sparing pattern of abnormal fetal growth in pregnant women from New York City after maternal Zika virus infection.

Walker CL, Merriam AA, Ohuma EO, Dighe MK, Gale M Jr, Rajagopal L, Papageorghiou AT, Gyamfi-Bannerman C, Adams Waldorf KM.
Am J Obstet Gynecol. 2018 Aug;219(2):187.e1-187.e20. doi: 10.1016/j.ajog.2018.04.047. Epub 2018 May 5. PMID: 29738748

Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses.

Athmer J, Fehr AR, Grunewald ME, Qu W, Wheeler DL, Graepel KW, Channappanavar R, Sekine A, Aldabeeb DS, Gale M Jr, Denison MR, Perlman S.
MBio. 2018 May 1;9(3). pii: e00272-18. doi: 10.1128/mBio.00272-18. PMID: 29717007

RIG-I and Other RNA Sensors in Antiviral Immunity.

Chow KT, Gale M Jr, Loo YM.
Annu Rev Immunol. 2018 Apr 26;36:667-694. doi: 10.1146/annurev-immunol-042617-053309. PMID: 29677479

Interleukin-1β Signaling in Dendritic Cells Induces Antiviral Interferon Responses.

Aarreberg LD, Wilkins C, Ramos HJ, Green R, Davis MA, Chow K, Gale M Jr.
MBio. 2018 Mar 20;9(2). pii: e00342-18. doi: 10.1128/mBio.00342-18.PMID: 29559569

Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART.

Fisher BS, Green RR, Brown RR, Wood MP, Hensley-McBain T, Fisher C, Chang J, Miller AD, Bosche WJ, Lifson JD, Mavigner M, Miller CJ, Gale M Jr, Silvestri G, Chahroudi A, Klatt NR, Sodora DL.
PLoS Pathog. 2018 Feb 21;14(2):e1006871. doi: 10.1371/journal.ppat.1006871. eCollection 2018 Feb. PMID: 29466439

Splenic macrophages are required for protective innate immunity against West Nile virus.

Bryan MA, Giordano D, Draves KE, Green R, Gale M Jr, Clark EA.
PLoS One. 2018 Feb 6;13(2):e0191690. doi: 10.1371/journal.pone.0191690. eCollection 2018.PMID:29408905

Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain.

Adams Waldorf KM, Nelson BR, Stencel-Baerenwald JE, Studholme C, Kapur RP, Armistead B, Walker CL, Merillat S, Vornhagen J, Tisoncik-Go J, Baldessari A, Coleman M, Dighe MK, Shaw DWW, Roby JA, Santana-Ufret V, Boldenow E, Li J, Gao X, Davis MA, Swanstrom JA, Jensen K, Widman DG, Baric RS, Medwid JT, Hanley KA, Ogle J, Gough GM, Lee W, English C, Durning WM, Thiel J, Gatenby C, Dewey EC, Fairgrieve MR, Hodge RD, Grant RF, Kuller L, Dobyns WB, Hevner RF, Gale M Jr, Rajagopal L.
Nat Med. 2018 Mar;24(3):368-374. doi: 10.1038/nm.4485. Epub 2018 Feb 5. PMID:29400709

cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses.

Hahn WO, Butler NS, Lindner SE, Akilesh HM, Sather DN, Kappe SH, Hamerman JA, Gale M Jr, Liles WC, Pepper M.
JCI Insight. 2018 Jan 25;3(2). pii: 94142. doi: 10.1172/jci.insight.94142. eCollection 2018 Jan 25. PMID:29367469