2019

Strong TH1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy.

Chamcha V, Reddy PBJ, Kannanganat S, Wilkins C, Gangadhara S, Velu V, Green R, Law GL, Chang J, Bowen JR, Kozlowski PA, Lifton M, Santra S, Legere T, Chea LS, Chennareddi L, Yu T, Suthar MS, Silvestri G, Derdeyn CA, Gale M Jr, Villinger F, Hunter E, Amara RR.
Sci Transl Med.. 2019 Nov 20;11(519). pii: eaav1800. doi: 10.1126/scitranslmed.aav1800. PMID: 31748228

RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions.

Schwerk J, Soveg FW, Ryan AP, Thomas KR, Hatfield LD, Ozarkar S, Forero A, Kell AM, Roby JA, So L, Hyde JL, Gale M Jr, Daugherty MD, Savan R.
Nat Immunol.. 2019 Dec;20(12):1610-1620. doi: 10.1038/s41590-019-0527-6. Epub 2019 Nov 18. PMID: 31704931

Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control.

Barrenas F, Raehtz K, Xu C, Law L, Green RR, Silvestri G, Bosinger SE, Nishida A, Li Q, Lu W, Zhang J, Thomas MJ, Chang J, Smith E, Weiss JM, Dawoud RA, Richter GH, Trichel A, Ma D, Peng X, Komorowski J, Apetrei C, Pandrea I, Gale M Jr.
nature communications.. 2019 Nov 8;10(1):5101. doi: 10.1038/s41467-019-12987-9. PMID: 31704931

Immune Evasion Strategies Used by Zika Virus to Infect the Fetal Eye and Brain.

Nelson BR, Roby JA, Dobyns WB, Rajagopal L, Gale M Jr, Adams Waldorf KM.
Viral Immunology.. 2019 Nov 5. doi: 10.1089/vim.2019.0082. doi: 10.1089/vim.2019.0082. PMID: 31687902

Microglia in Memory Decline from Zika Virus and West Nile Virus Infection.

Tisoncik-Go J, Gale M Jr.
Trends Neurosci.. 2019 Sep 5. pii: S0166-2236(19)30159-6. doi: 10.1016/j.tins.2019.08.009. [Epub ahead of print]. PMID: 31495452

Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons.

Forero A, Ozarkar S, Li H, Lee CH, Hemann EA, Nadjsombati MS, Hendricks MR, So L, Green R, Roy CN, Sarkar SN, von Moltke J, Anderson SK, Gale M Jr, Savan R.
Immunity. 2019 Sep 17;51(3):451-464.e6. doi: 10.1016/j.immuni.2019.07.007. Epub 2019 Aug 27. PMID: 31471108

STING is required for host defense against neuropathological West Nile virus infection.

McGuckin Wuertz K, Treuting PM, Hemann EA, Esser-Nobis K, Snyder AG, Graham JB, Daniels BP, Wilkins C, Snyder JM, Voss KM, Oberst A, Lund J, Gale M Jr.
PLoS Pathog. 2019 Aug 15;15(8):e1007899. doi: 10.1371/journal.ppat.1007899. eCollection 2019 Aug. PMID: 31415679

Risk of Zika microcephaly correlates with features of maternal antibodies.

Robbiani DF, Olsen PC, Costa F, Wang Q, Oliveira TY, Nery N Jr, Aromolaran A, do Rosário MS, Sacramento GA, Cruz JS, Khouri R, Wunder EA Jr, Mattos A, de Paula Freitas B, Sarno M, Archanjo G, Daltro D, Carvalho GBS, Pimentel K, de Siqueira IC, de Almeida JRM, Henriques DF, Lima JA, Vasconcelos PFC, Schaefer-Babajew D, Azzopardi SA, Bozzacco L, Gazumyan A, Belfort R Jr, Alcântara AP, Carvalho G, Moreira L, Araujo K, Reis MG, Keesler RI, Coffey LL, Tisoncik-Go J, Gale M Jr, Rajagopal L, Adams Waldorf KM, Dudley DM, Simmons HA, Mejia A, O'Connor DH, Steinbach RJ, Haese N, Smith J, Lewis A, Colgin L, Roberts V, Frias A, Kelleher M, Hirsch A, Streblow DN, Rice CM, MacDonald MR, de Almeida ARP, Van Rompay KKA, Ko AI, Nussenzweig MC.
J Exp Med.. 2019 Oct 7;216(10):2302-2315. doi: 10.1084/jem.20191061. Epub 2019 Aug 14. PMID: 31413072

RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection.

Stone AEL, Green R, Wilkins C, Hemann EA, Gale M Jr.
Nat Commun.. 2019 Aug 13;10(1):3649. doi: 10.1038/s41467-019-11250-5. PMID: 31409781

Dendritic cell-associated MAVS is required to control West Nile virus replication and ensuing humoral immune responses.

Roe K, Giordano D, Young LB, Draves KE, Holder U, Suthar MS, Gale M Jr, Clark EA.
PLoS One.. 2019 Jun 26;14(6):e0218928. doi: 10.1371/journal.pone.0218928. eCollection 2019. PMID: 31242236

Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus.

Hemann EA, Green R, Turnbull JB, Langlois RA, Savan R, Gale M Jr.
Nat Immunol.. 2019 Aug;20(8):1035-1045. doi: 10.1038/s41590-019-0408-z. Epub 2019 Jun 24. PMID: 31235953

DHX15 Is a Coreceptor for RLR Signaling That Promotes Antiviral Defense Against RNA Virus Infection.

Pattabhi S, Knoll ML, Gale M , Jr, Loo YM.
J Interferon Cytokine Res. 2019 Jun;39(6):331-346. doi: 10.1089/jir.2018.0163. Epub 2019 May 15.

Comparative analysis of African and Asian lineage-derived Zika Virus strains reveals differences in activation of and sensitivity to antiviral innate immunity.

Esser-Nobis K, Aarreberg LD, Roby JA, Fairgrieve MR, Green R, Gale M Jr.
J Virol. 2019 Jun 14;93(13). pii: e00640-19. doi: 10.1128/JVI.00640-19. Print 2019 Jul 1.

Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection.

Hensley-McBain T, Wu MC, Manuzak JA, Cheu RK, Gustin A, Driscoll CB, Zevin AS, Miller CJ, Coronado E, Smith E, Chang J, Gale M Jr, Somsouk M, Burgener AD, Hunt PW, Hope TJ, Collier AC, Klatt NR.
PLoS Pathog. 2019 Apr 11;15(4):e1007672. doi: 10.1371/journal.ppat.1007672. eCollection 2019 Apr. PMID: 30973942

Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING.

Aarreberg LD, Esser-Nobis K, Driscoll C, Shuvarikov A, Roby JA, Gale M Jr.
Mol Cell. 2019 Mar 22. pii: S1097-2765(19)30149-2. doi: 10.1016/j.molcel.2019.02.038. PMID: 30952515

Hepatic IFN-Induced Protein with Tetratricopeptide Repeats Regulation of HCV Infection.

Ishida Y, Kakuni M, Bang BR, Sugahara G, Lau DT, Tateno-Mukaidani C, Li M, Gale M Jr, Saito T.
J Interferon Cytokine Res. 2019 Mar;39(3):133-146. doi: 10.1089/jir.2018.0103. PMID: 30844328

Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation.

Negash AA, Olson RM, Griffin S, Gale M Jr.
PLoS Pathog. 2019 Feb 27;15(2):e1007593. doi: 10.1371/journal.ppat.1007593. eCollection 2019 Feb. PMID: 30811485

Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation.

Davis MA, Fairgrieve MR, Den Hartigh A, Yakovenko O, Duvvuri B, Lood C, Thomas WE, Fink SL, Gale M Jr.
Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5061-5070. doi: 10.1073/pnas.1818598116. Epub 2019 Feb 22. PMID:30796192

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.

Daniels BP, Kofman SB, Smith JR, Norris GT, Snyder AG, Kolb JP, Gao X, Locasale JW, Martinez J, Gale M Jr, Loo YM, Oberst A.
Immunity. 2019 Jan 15;50(1):64-76.e4. doi: 10.1016/j.immuni.2018.11.017. Epub 2019 Jan 8. PMID: 30635240

Cell-type specificity and functional redundancy of RIG-I-like receptors in innate immune sensing of Coxsackievirus B3 and encephalomyocarditis virus.

Francisco E, Suthar M, Gale M Jr, Rosenfeld AB, Racaniello VR.
Virology. 2019 Feb;528:7-18. doi: 10.1016/j.virol.2018.12.003. Epub 2018 Dec 11. PMID: 30550976

IRF5 regulates unique subset of genes in dendritic cells during West Nile virus infection.

Chow KT, Driscoll C, Loo YM, Knoll M, Gale M Jr.
J Leukoc Biol. 2019 Feb;105(2):411-425. doi: 10.1002/JLB.MA0318-136RRR. Epub 2018 Nov 20. PMID: 30457675