2020

SARS-CoV-2 Serologic Assays in Control and Unknown Populations Demonstrate the Necessity of Virus Neutralization Testing

Jennifer A Rathe, Emily A Hemann, Julie Eggenberger, Zhaoqi Li, Megan L Knoll, Caleb Stokes, Tien-Ying Hsiang, Jason Netland, Kennidy K Takehara, Marion Pepper, Michael Gale
J Infect Dis. 2020 Dec 25;jiaa797. doi: 10.1093/infdis/jiaa797. Online ahead of print. PMID: 33367830

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19

Lauren B Rodda, Jason Netland, Laila Shehata, Kurt B Pruner, Peter A Morawski, Christopher D Thouvenel, Kennidy K Takehara, Julie Eggenberger, Emily A Hemann, Hayley R Waterman, Mitchell L Fahning, Yu Chen, Malika Hale, Jennifer Rathe, Caleb Stokes, Samuel Wrenn, Brooke Fiala, Lauren Carter, Jessica A Hamerman, Neil P King, Michael Gale Jr, Daniel J Campbell, David J Rawlings, Marion Pepper
Cell. 2021 Jan 7;184(1):169-183.e17. doi: 10.1016/j.cell.2020.11.029. Epub 2020 Nov 23. PMID: 33296701 PMCID: PMC7682481

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

Alicia T Widge, Nadine G Rouphael, Lisa A Jackson, Evan J Anderson, Paul C Roberts, Mamodikoe Makhene, James D Chappell, Mark R Denison, Laura J Stevens, Andrea J Pruijssers, Adrian B McDermott, Britta Flach, Bob C Lin, Nicole A Doria-Rose, Sijy O'Dell, Stephen D Schmidt, Kathleen M Neuzil, Hamilton Bennett, Brett Leav, Mat Makowski, Jim Albert, Kaitlyn Cross, Venkata-Viswanadh Edara, Katharine Floyd, Mehul S Suthar, Wendy Buchanan, Catherine J Luke, Julie E Ledgerwood, John R Mascola, Barney S Graham, John H Beigel, mRNA-1273 Study Group
N Engl J Med. 2021 Jan 7;384(1):80-82. doi: 10.1056/NEJMc2032195. Epub 2020 Dec 3. Online ahead of print. PMID: 33270381 PMCID: PMC7727324

Characterizing Viral Infection by Electron Microscopy: Lessons from the Coronavirus Disease 2019 Pandemic

Shreeram Akilesh, Roberto F Nicosia, Charles E Alpers, Maria Tretiakova, Tien-Ying Hsiang, Michael Gale Jr, Kelly D Smith
Am J Pathol. 2020 Nov 20;S0002-9440(20)30503-4. doi: 10.1016/j.ajpath.2020.11.003. Online ahead of print. PMID: 33227297 PMCID: PMC7678435

De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

Linsky TW, Vergara R, Codina N, Nelson JW, Walker MJ, Su W, Barnes CO, Hsiang TY, Esser-Nobis K, Yu K, Reneer ZB, Hou YJ, Priya T, Mitsumoto M, Pong A, Lau UY, Mason ML, Chen J, Chen A, Berrocal T, Peng H, Clairmont NS, Castellanos J, Lin YR, Josephson-Day A, Baric RS, Fuller DH, Walkey CD, Ross TM, Swanson R, Bjorkman PJ, Gale M Jr, Blancas-Mejia LM, Yen HL, Silva DA..
Science . 2020 Nov 5:eabe0075. doi: 10.1126/science.abe0075. Online ahead of print. PMID: 33154107

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

Evan J Anderson, Nadine G Rouphael, Alicia T Widge, Lisa A Jackson, Paul C Roberts, Mamodikoe Makhene, James D Chappell, Mark R Denison, Laura J Stevens, Andrea J Pruijssers, Adrian B McDermott, Britta Flach, Bob C Lin, Nicole A Doria-Rose, Sijy O'Dell, Stephen D Schmidt, Kizzmekia S Corbett, Phillip A Swanson 2nd, Marcelino Padilla, Kathy M Neuzil, Hamilton Bennett, Brett Leav, Mat Makowski, Jim Albert, Kaitlyn Cross, Venkata Viswanadh Edara, Katharine Floyd, Mehul S Suthar, David R Martinez, Ralph Baric, Wendy Buchanan, Catherine J Luke, Varun K Phadke, Christina A Rostad, Julie E Ledgerwood, Barney S Graham, John H Beigel, mRNA-1273 Study Group
N Engl J Med. 2020 Dec 17;383(25):2427-2438. doi: 10.1056/NEJMoa2028436. Epub 2020 Sep 29. PMID: 32991794 PMCID: PMC7556339

New horizons in adjuvants for vaccine development

Reed SG, Tomai M, Gale MJ Jr.
Curr Opin Immunol. 2020 Oct 7;65:97-101. doi: 10.1016/j.coi.2020.08.008. Online ahead of print. PMID: 33038865

Cell type- and replication stage-specific influenza virus responses in vivo

Fay EJ, Aron SL, Macchietto MG, Markman MW, Esser-Nobis K, Gale M Jr, Shen S, Langlois RA.
PLoS Pathog. 2020 Aug 13;16(8):e1008760. doi: 10.1371/journal.ppat.1008760. eCollection 2020 Aug. PMID: 32790753

A Geroscience Approach to Preventing Pathologic Consequences of COVID-19

Dou Y, Fatemi S, Darvas M, Gale M Jr, Ladiges W.
J Interferon Cytokine Res. 2020 Sep;40(9):433-437. doi: 10.1089/jir.2020.29018.dou. Epub 2020 Aug 13. PMID: 32790488

Proteome-Wide Zika Virus CD4 T Cell Epitope and HLA Restriction Determination

Campbell VL, Nguyen L, Snoey E, McClurkan CL, Laing KJ, Dong L, Sette A, Lindestam Arlehamn CS, Altmann DM, Boyton RJ, Roby JA, Gale M Jr, Stone M, Busch MP, Norris PJ, Koelle DM.
Immunohorizons. 2020 Aug 4;4(8):444-453. doi: 10.4049/immunohorizons.2000068. PMID: 32753403

An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

Erasmus JH, Khandhar AP, O'Connor MA, Walls AC, Hemann EA, Murapa P, Archer J, Leventhal S, Fuller JT, Lewis TB, Draves KE, Randall S, Guerriero KA, Duthie MS, Carter D, Reed SG, Hawman DW, Feldmann H, Gale M Jr, Veesler D, Berglund P, Fuller DH..
Sci Transl Med. 2020 Aug 5;12(555):eabc9396. doi: 10.1126/scitranslmed.abc9396. Epub 2020 Jul 20. PMID: 32690628

Spatiotemporal Dynamics of Innate Immune Signaling via RIG-I-like Receptors

Esser-Nobis K, Hatfield LD, Gale M Jr.
Proc Natl Acad Sci U S A. 2020 Jun 22;201921861. doi: 10.1073/pnas.1921861117. Online ahead of print.

Single-dose Replicating RNA Vaccine Induces Neutralizing Antibodies Against SARS-CoV-2 in Nonhuman Primates.

Erasmus JH, Khandhar AP, Walls AC, Hemann EA, O'Connor MA, Murapa P, Archer J, Leventhal S, Fuller J, Lewis T, Draves KE, Randall S, Guerriero KA, Duthie MS, Carter D, Reed SG, Hawman DW, Feldmann H, Gale M Jr, Veesler D, Berglund P, Fuller DH.
bioRxiv.. 2020 May 28:2020.05.28.121640. doi: 10.1101/2020.05.28.121640. Preprint. PMID: 32511417

The Early Local and Systemic Type I Interferon Responses to Ultraviolet B Light Exposure Are cGAS Dependent.

Skopelja-Gardner S, An J, Tai J, Tanaka L, Sun X, Hermanson P, Baum R, Kawasumi M, Green R, Gale M Jr, Kalus A, Werth VP, Elkon KB.
Sci Rep.. 2020 May 13;10(1):7908. doi: 10.1038/s41598-020-64865-w.

Systematic Profiling of Full-Length Ig and TCR Repertoire Diversity in Rhesus Macaque Through Long Read Transcriptome Sequencing.

Brochu HN, Tseng E, Smith E, Thomas MJ, Jones AM, Diveley KR, Law L, Hansen SG, Picker LJ, Gale M Jr, Peng X.
J Immunol. 2020 May 6;ji1901256. doi: 10.4049/jimmunol.1901256. Online ahead of print.

Innate Immunity in Hepatitis C Virus Infection.

Schwerk J, Negash A, Savan R, Gale M Jr.
Cold Spring Harb Perspect Med.. 2020 Apr 27;a036988. doi: 10.1101/cshperspect.a036988. Online ahead of print.

Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques.

Manuzak JA, Zevin AS, Cheu R, Richardson B, Modesitt J, Hensley-McBain T, Miller C, Gustin AT, Coronado E, Gott T, Fang M, Cartwright M, Wangari S, Agricola B, May D, Smith E, Hampel HB, Gale M, Cameron CM, Cameron MJ, Smedley J, Klatt NR.
Mucosal Immunol. 2020 May;13(3):471-480. doi: 10.1038/s41385-019-0238-1. Epub 2019 Dec 4. PMID: 31797911

RIG-I-like Receptor Activation Drives Type I IFN and Antiviral Signaling to Limit Hantaan Orthohantavirus Replication.

Kell AM, Hemann EA, Turnbull JB, Gale M Jr.
PLoS Pathog. 2020 Apr 24;16(4):e1008483. doi: 10.1371/journal.ppat.1008483. eCollection 2020 Apr.

Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling.

Roby JA, Esser-Nobis K, Dewey-Verstelle EC, Fairgrieve MR, Schwerk J, Lu AY, Soveg FW, Hemann EA, Hatfield LD, Keller BC, Shapiro A, Forero A, Stencel-Baerenwald JE, Savan R, Gale M Jr.
Cell . 2020 Apr 7;9(4):899. doi: 10.3390/cells9040899.

Engagement of Monocytes, NK Cells, and CD4+ Th1 Cells by ALVAC-SIV Vaccination Results in a Decreased Risk of SIVmac251 Vaginal Acquisition.

Gorini G, Fourati S, Vaccari M, Rahman MA, Gordon SN, Brown DR, Law L, Chang J, Green R, Barrenäs F, Liyanage NPM, Doster MN, Schifanella L, Bissa M, Silva de Castro I, Washington-Parks R, Galli V, Fuller DH, Santra S, Agy M, Pal R, Palermo RE, Tomaras GD, Shen X, LaBranche CC, Montefiori DC, Venzon DJ, Trinh HV, Rao M, Gale M Jr, Sekaly RP, Franchini G.
PLoS Pathog . 2020 Mar 12;16(3):e1008377. doi: 10.1371/journal.ppat.1008377. eCollection 2020 Mar.

African Green Monkeys Avoid SIV Disease Progression by Preventing Intestinal Dysfunction and Maintaining Mucosal Barrier Integrity.

Raehtz KD, Barrenäs F, Xu C, Busman-Sahay K, Valentine A, Law L, Ma D, Policicchio BB, Wijewardana V, Brocca-Cofano E, Trichel A, Gale M Jr, Keele BF, Estes JD, Apetrei C, Pandrea I.
PLoS Pathog . 2020 Mar 2;16(3):e1008333. doi: 10.1371/journal.ppat.1008333. eCollection 2020 Mar.

Immune Predictors of Mortality After Ribonucleic Acid Virus Infection.

Graham JB, Swarts JL, Menachery VD, Gralinski LE, Schäfer A, Plante KS, Morrison CR, Voss KM, Green R, Choonoo G, Jeng S, Miller DR, Mooney MA, McWeeney SK, Ferris MT, Pardo-Manuel de Villena F, Gale M, Heise MT, Baric RS, Lund JM.
J Infect Dis. 2020 Mar 2;221(6):882-889. doi: 10.1093/infdis/jiz531. PMID: 31621854

Human DNA-PK activates a STING-independent DNA sensing pathway.

Burleigh K, Maltbaek JH, Cambier S, Green R, Gale M Jr, James RC, Stetson DB.
Sci Immunol.. 2020 Jan 24;5(43). pii: eaba4219. doi: 10.1126/sciimmunol.aba4219. PMID: 31980485