2022

Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine.

Hawman DW, Meade-White K, Clancy C, Archer J, Hinkley T, Leventhal SS, Rao D, Stamper A, Lewis M, Rosenke R, Krieger K, Randall S, Khandhar AP, Hao L, Hsiang TY, Greninger AL, Gale M Jr, Berglund P, Fuller DH, Rosenke K, Feldmann H, Erasmus JH.
EBioMedicine. 2022 Sep;83:104196. doi: 10.1016/j.ebiom.2022.104196. Epub 2022 Aug 4. PMID: 35932641

Dynamics of SARS-CoV-2 VOC neutralization and novel mAb reveal protection against Omicron.

Hao L, Hsiang TY, Dalmat RR, Ireton R, Morton J, Stokes C, Netland J, Hale M, Thouvenel C, Wald A, Franko NM, Huden K, Chu H, Greninger A, Tilles S, Barrett LK, Van Voorhis WC, Munt J, Scobey T, Baric RS, Rawlings D, Pepper M, Drain PK, Gale M.
medRxiv. 2022 Aug 16:2022.08.12.22278720. doi: 10.1101/2022.08.12.22278720. Preprint. PMID: 36032965

Extended Remdesivir Infusion for Persistent Coronavirus Disease 2019 Infection.

Martinez MA, Chen TY, Choi H, Hwang M, Navarathna D, Hao L, Gale M Jr, Camus G, Ramirez HE, Jinadatha C..
Open Forum Infect Dis. 2022 Jul 29;9(8):ofac382. doi: 10.1093/ofid/ofac382. eCollection 2022 Aug. PMID: 36039098

Innate immune regulation in HIV latency models.

Olson RM, Gornalusse G, Whitmore LS, Newhouse D, Tisoncik-Go J, Smith E, Ochsenbauer C, Hladik F, Gale M.
Retrovirology. 2022 Jul 8;19(1):15. doi: 10.1186/s12977-022-00599-z. PMID: 35804422

Myelin Protein Zero Immunohistochemistry Is Not a Reliable Marker of Extrinsic Mucosal Innervation in Patients With Hirschsprung Disease.

Kapur RP, Tisoncik-Go J, Gale M.
Pediatr Dev Pathol. 2022 Jul-Aug;25(4):388-396. doi: 10.1177/10935266211059395. Epub 2021 Dec 14. PMID: 34904460

Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice.

Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vögeli B, Krüger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetič A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale M Jr, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D.
JSci Transl Med. 2022 May 25;14(646):eabn1252. doi: 10.1126/scitranslmed.abn1252. Epub 2022 May 25. PMID: 35412328

T cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibodies and disease severity.

Elyanow R, Snyder TM, Dalai SC, Gittelman RM, Boonyaratanakornkit J, Wald A, Selke S, Wener MH, Morishima C, Greninger AL, Gale M Jr, Hsiang TY, Jing L, Holbrook MR, Kaplan IM, Zahid HJ, May DH, Carlson JM, Baldo L, Manley T, Robins HS, Koelle DM.
JCI Insight. 2022 May 23;7(10):e150070. doi: 10.1172/jci.insight.150070. PMID: 35439166

Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity.

Rodda LB, Morawski PA, Pruner KB, Fahning ML, Howard CA, Franko N, Logue J, Eggenberger J, Stokes C, Golez I, Hale M, Gale M Jr, Chu HY, Campbell DJ, Pepper M.
Cell. 2022 Apr 28;185(9):1588-1601.e14. doi: 10.1016/j.cell.2022.03.018. Epub 2022 Mar 17. PMID: 35413241

Performance of anterior nares and tongue swabs for nucleic acid, Nucleocapsid, and Spike antigen testing for detecting SARS-CoV-2 against nasopharyngeal PCR and viral culture.

Montaño MA, Bemer MJ, Heller KB, Meisner A, Marfatia Z, Rechkina EA, Padgett LR, Ahls CL, Rains D, Hao L, Hsiang TY, Cangelosi GA, Greninger AL, Cantera JL, Golden A, Peck RB, Boyle DS, Gale M Jr, Drain PK.
Int J Infect Dis. 2022 Apr;117:287-294. doi: 10.1016/j.ijid.2022.02.009. Epub 2022 Feb 9. PMID: 35149246

T cell response to intact SARS-CoV-2 includes coronavirus cross-reactive and variant-specific components.

Jing L, Wu X, Krist MP, Hsiang TY, Campbell VL, McClurkan CL, Favors SM, Hemingway LA, Godornes C, Tong DQ, Selke S, LeClair AC, Pyo CW, Geraghty DE, Laing KJ, Wald A, Gale M Jr, Koelle DM.
JCI Insight. 2022 Mar 22;7(6):e158126. doi: 10.1172/jci.insight.158126. PMID: 35133988

ZIKV can infect human term placentas in the absence of maternal factors.

Villazana-Kretzer DL, Wuertz KM, Newhouse D, Damicis JR, Dornisch EM, Voss KM, Muruato AE, Paymaster JA, Schmiedecke SS, Edwards SM, Napolitano PG, Tisoncik-Go J, Ieronimakis N, Gale M Jr.
Commun Biol. 2022 Mar 18;5(1):243. doi: 10.1038/s42003-022-03158-6. PMID: 35304593

Biological functions of DEAD/DEAH-box RNA helicases in health and disease.

Andrisani O, Liu Q, Kehn P, Leitner WW, Moon K, Vazquez-Maldonado N, Fingerman I, Gale M Jr.
Nat Immunol. 2022 Mar;23(3):354-357. doi: 10.1038/s41590-022-01149-7. PMID: 35194205

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern.

Hawman DW, Meade-White K, Archer J, Leventhal SS, Wilson D, Shaia C, Randall S, Khandhar AP, Krieger K, Hsiang TY, Gale M, Berglund P, Fuller DH, Feldmann H, Erasmus JH.
Elife. 2022 Feb 22;11:e75537. doi: 10.7554/eLife.75537. PMID: 35191378

Single-Cell-Based High-Throughput Ig and TCR Repertoire Sequencing Analysis in Rhesus Macaques.

Walsh ES, Tollison TS, Brochu HN, Shaw BI, Diveley KR, Chou H, Law L, Kirk AD, Gale M Jr, Peng X.
J Immunol. 2022 Feb 1;208(3):762-771. doi: 10.4049/jimmunol.2100824. Epub 2022 Jan 5. PMID: 34987112